The Gradinaru Lab

Key publications

• Diffusion and Oligomerization States of the Muscarinic M1 Receptor in Live Cells - The Impact of Ligands and Membrane Disruptors 
  X. Zhou, H. Septien-Gonzalez, S. Husaini, R.J. Ward, G. Milligan, and C.C. Gradinaru, J. Phys. Chem. B (2024), 128, 4354-4366
• Delineating Structural Propensities of the 4E-BP2 Protein via Integrative Modeling and Clustering 
  T.E. Tsangaris, S. Smyth, G.W. Gomes, Z.H. Liu, M. Milchberg, A. Bah, G.A. Wasney, J.D. Forman-Kay, and C.C. Gradinaru, J. Phys. Chem. B (2023), 127, 7472–7486
• Multisite Phosphorylation and Binding Alter Conformational Dynamics of the 4E-BP2 Protein 
  S. Smyth, Z. Zhang, A. Bah, T.E. Tsangaris, J. Dawson, J.D. Forman-Kay, and C.C. Gradinaru, Biophysical Journal (2022), 121, 3049–3060
• Ligand Modulation of the Conformational Dynamics of the A_2A Adenosine Receptor Revealed by Single-Molecule Fluorescence 
  D.D. Fernandes, C. Neale, G.-N.W. Gomes, Y. Li, A. Malik, A. Pandey, A.P. Orazietti, X. Wang, L. Ye, R.S. Prosser, and C.C. Gradinaru, Scientific Reports (2021), 11, 5910
• Conformational Ensembles of an Intrinsically Disordered Protein Consistent with NMR, SAXS, and Single-Molecule FRET 
  G.-N.W. Gomes, M. Krzeminski, A. Namini, E. Martin, T. Mittag, T. Head-Gordon, J.D. Forman-Kay, and C.C. Gradinaru, J. Am. Chem. Soc. (2020), 142, 37, 15697-15710
• Non-cooperative 4E-BP2 Folding with Exchange between eIF4E-binding and Binding-incompatible States Allows for Tuning of CAP-dependent Translation Inhibition 
  J.E. Dawson, A. Bah, R.M. Vernon, Z. Zhang, H. Lin, N. Sonenberg, C.C. Gradinaru and J.D. Forman-Kay, Nat. Commun. (2020), 11, 3146
• Ligand-Induced Coupling between Oligomers of the M₂ Receptor and the G_i1 Protein in Live Cells 
  Y. Li, R.V. Shivnaraine, F. Huang, J.W. Wells and C.C. Gradinaru, Biophysical Journal (2018), 115, 881-895
• Insights into the Conformations and Dynamics of Intrinsically Disordered Proteins using Single-Molecule Fluorescence 
  G.-N. Gomes and C.C. Gradinaru, BBA Proteins and Proteomics (2017), 1865, 1696-1706
• Single-Molecule Analysis of the Supramolecular Organization of the M₂ Muscarinic Receptor and the Ga_i1 Protein 
  R.V. Shivnaraine, D.D. Fernandes, H. Ji, Y. Li, Z. Zhang, B. Kelly, N. Han, F. Huang, K.S. Sankar, D.N. Dubbins, J.V. Rocheleau, J.W. Wells and C.C. Gradinaru, J. Am. Chem. Soc. (2016), 138 (36), 11583-11598
• Conformations of a Metastable SH3 Domain Characterized by smFRET and an Excluded-Volume Polymer Model 
  A. Mazouchi, Z. Zhang, A. Bahram, G.-N. Gomes, H. Lin, J. Song, H.S. Chan, J.D. Forman-Kay and C.C. Gradinaru, Biophysical Journal (2016), 110, 1510-1522
• The Effect of Intrachain Electrostatic Repulsion on Conformational Disorder and Dynamics of the Sic1 Protein 
  B. Liu, D. Chia, V. Csizmok, P. Farber, J.D. Forman-Kay and C.C. Gradinaru, J. Phys. Chem. B (2014), 118 (15), 4088–4097
• The Effect of Brownian Motion of Fluorescent Probes on Measuring Nanoscale Distances by Forster Resonance Energy Transfer 
  D. Badali and C.C. Gradinaru, J. Chem. Phys. (2011), 134, 225102
• An Unusual Pathway of Excitation Energy Deactivation in Carotenoids: Singlet to Triplet Conversion on an Ultrafast Time Scale in a Photosynthetic Antenna 
  C.C. Gradinaru, J.T.M. Kennis, E. Papagiannakis, I.H.M van Stokkum, R.J. Cogdell, G.R. Fleming, R.A. Niederman and R. van Grondelle, PNAS (2001), 98, 2364-2369

Full list of publications >>