GPCR pharmocology

GPCR pharmacology and signal mechanisms can be explained by functional fluorescent reporter assays, NMR experiments, and single molecule methods. Ongoing studies in the lab address questions such as the following: How do metals, lipids, and other adjuvants modulate signaling in the cell? Where does the energy come from to allow for receptor activation? How does a drug bias a given signal pathway? How is activation communicated across a protein-protein interface to a G protein?



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