Robert Scott Prosser (0000-0001-9351-178X) (


  • Huang, S.K., Pandey A., Tran, P.D., Villlanueva, N.L., Kitao, A., Sunahara, R.K., Sljoka, A., Prosser, R.S., Delineating the conformational landscape of the adenosine A2A receptor during G protein couplingCell, 184, 1884-1894 Cell
  • Baksh, K.A., Pichugin D., Prosser, R.S., Zamble, D.B., Allosteric regulation of the nickel-responsive NikR transcription factor from Helicobacter pylori, J. Bio. Chem.,  296, 100069



  • Staus, D.P., Wingler, L.M. Pichugin, D., Prosser, R.S., Lefkowitz, R.J., Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein–coupled receptorsJ. Biol. Chem., 294(36), 13218-13223 J.B.C.
  • Mehrabi, P., Di Pietrantonio, C., Kim, T.H., Sljoka, A., Taverner., K., Ing, C., Kruglyak, N. Pomes, R. Pai, E.F. Prosser, R.S., Substrate-Based Allosteric Regulation of a Homodimeric EnzymeJ. Am. Chem. Soc., 141 (29)11540-11556 J.A.C.S.


  • Ye, L., Neale, C., Sljoka, A., Lyda, B., Pichugin, D., Tsuchimura, N., Larda, S. T., Pomes, R., Garcia, A. E., Ernst, O. P., Sunahara, R. K., Prosser, R. S.. Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations.​ Nature Comm. 9, Article: 1372 Nature communications


  • Brea, R. J., Cole, C. M., Lyda, B. R., Ye, L., Peosser, R. S., Sunahara, R. K., Devaraj, N. K., In Situ Reconstruction of the Adensoside A2A Receptor in spontaneously formed synthetic liposomes. J. A. Chem. Soc. 139 (3607) ACS publications
  • Kim, T. H., Mehrabi, P., Ren, Z., Sljoka, A., Ing, C., Bezginov, A., Ye, L., Pomes, R., Prosser. R. S., and Pai, E. F.. The role of dimer asymmetry and protomer dynamics in enzyme catalysis. Science 355 (6322) Science


  • Staus, D. P., Strachan, R. T., Manglik, A., Pani, B., Kahsai, A. W., Kim, T. H., Wingler, L. M., Ahn, S., Chatterjee, A., Masoudi, A., Kruse, A. C., Pardon, E., Steyaert, J., Weis, W. I., Prosser, R. S., Kobilka, B. K., Costa, T., and Lefkowitz, R., J.. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.​ Nature 535 (7612), 448-452 Nature  
  • Ye, L., Van Eps, N., Zimmer, M., Ernst, O. P., and Prosser, R. S.. Activation of the A2A adenosine G-protein-coupled receptor by conformational selection. Nature 533 (7602), 265-268 Nature  
  • Alvares, R. D. A., Lau, J. Y. C., Macdonald, P. M., Cunningham, C. H., and Prosser, R. S.. Direct quantitative 13C-filtered 1H magnetic resonance imaging of PEGylated biomacromolecules in vivo. Magnetic resonance in medicine. doi:10.1002/mrm.26237 PubMed
  • Alvares, R. D. A., Hasabnis, A., Prosser, R. S., and Macdonald, P. M.. Quantitative detection of PEGylated biomacromolecules in biological fluids by NMR. Analytical Chemistry 88 (7), 3730-3738 ACS Publications


  • Larda, S.T., Pichugin, D., and Prosser, R. S.. Site-specific labeling of protein lysine residues and N-terminal amino gruops with indoles and indole-derivatives.
    Bioconjugate Chemistry 26 (12), 2376-2383 ACS Publications  
  • Manglik, A., Kim, T. H., Masureel, M., Altenbach, C., Yang, Z., Hilger, D., Kobilka, T. S., Thian, F. S., Hubbell, W. L.*, Prosser, R. S.*, and Kobilka, B. K.* (* Co-corresponding authors) Structural insights into the dynamic process of β2-adrenergic receptor signaling. 
    Cell 161 (5), 1101-1111  
  • Prosser, R. S. and Kim, T. H. Nuts and Bolts of CF3 and CH3 NMR. Towards an Understanding of Conformational Exchange of GPCRs. 
    To be published in G-Protein-Coupled Receptors in Drug Discovery, in the lab protocol series Methods in Molecular Biology, Springer 
  • Ye, L., Larda, S. T., Feng, Y. Q., Manglik, A., and Prosser, R. S. A Comparison of Chemical Shift Sensitivity of Trifluoromethyl Tags – Optimizing Resolution in 19F NMR Studies of Proteins.
    J Biomol NMR. 2015 Mar 27. [Epub ahead of print] PubMed


  • Hoang J, Prosser RS. Conformational Selection and Functional Dynamics of Calmodulin: A 19F NMR Study.
    Biochemistry. 2014 Aug 22. [Epub ahead of print]  PubMed
  • Prosser RS. New pipelines for novel allosteric GPCR modulators.
    Biophys J. 2014 Jul 15;107(2):287-8.  PubMed
  • Alvares R, Gupta S, Macdonald PM, Prosser RS. Temperature and pressure based NMR studies of detergent micelle phase equilibria.
    J Phys Chem B. 2014 May 29;118(21):5698-706.  PubMed


  • Kitevski-Leblanc JL, Hoang J, Thach W, Larda ST, Prosser RS. 19F NMR Studies of a Desolvated Near-Native Protein Folding Intermediate.
    Biochemistry. 2013 Jul 17;135(28):10533-41. PubMed
  • Larda ST, Simonetti K, Al-Abdul-Wahid MS, Sharpe S, Prosser RS. Dynamic Equilibria between Monomeric and Oligomeric Misfolded States of the Mammalian Prion Protein Measured by (19)F NMR.
    J Am Chem Soc. 2013 Jul 17;135(28):10533-41. PubMed
  • Kim TH, Chung KY, Manglik A, Hansen AL, Dror RO, Mildorf TJ, Shaw DE, Kobilka BK, Prosser RS.The role of ligands on the equilibria between functional States of a g protein-coupled receptor. 
    J Am Chem Soc. 2013 Jun 26;135(25):9465-74. PubMed
  • Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK. The Dynamic Process of β(2)-Adrenergic Receptor Activation. 
    Cell. 2013 Jan 31;152(3):532-42.    PubMed


  • Larda ST, Bokoch MP, Evanics F, Prosser RS. Lysine methylation strategies for characterizing protein conformations by NMR
    J Biomol NMR 2012 Oct;54(2):199-209    PubMed 
  • Chung KY, Kim TH, Manglik A, Alvares R, Kobilka BK, Prosser RS. Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor
    J Biol Chem 2012 Oct 19;287(43):36305-11    PubMed 
  • Alvares RD, Tulumello DV, Macdonald PM, Deber CM, Prosser RS. Effects of a polar amino acid substitution on helix formation and aggregate size along the detergent-induced peptide folding pathway
    Biochim Biophys Acta 2012 Sep 29. pii: S0005-2736(12)00345-8    PubMed

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