Our research focuses on enzyme complexes and G Protein-Coupled Receptors (GPCRs), with the goal of understanding mechanistic and biophysical underpinnings to function. Modern drug discovery and pharmacology is experiencing a renaissance, thanks to innovations in high-throughput chemistry and screening, and structural biology. NMR and other biophysical methods - FRET (Fluorescence Resonance Energy Transfer) and BRET (Bioluminescence Resonance Energy Transfer), and plate reader based functional assays - allow us to construct a dynamic ensemble perspective of protein structure. Ligands, drug fragments, and entire protein complexes are all amenable to NMR, and help us understand function and advance drug discovery.
